Anaphase promoting complex: structure and expression
Hamzeh Rahimi
Broschiertes Buch

Anaphase promoting complex: structure and expression

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The anaphase promoting complex (APC) is the largest Cullin-RING E3 ligase that plays a critical role in cell cycle control and known as target of anti-cancer agents. APC regulates the onset of chromosome separation and mitotic exit via securin and cyclin B degradation, respectively. APC controls this process by mediating ubiquitin conjugation to substrates such as cyclin B and securin. The objective of this study was to evaluate the expression pattern of APC subunits in cancer cell lines and AML patients. Moreover, inhibitory compounds were designed based on the 3D structure of the APC and the...