Written and edited by experts in the field, this collection provides an overview of recent progress in our understanding of the causal mechanisms essential for angiogenesis and lymphangiogenesis in normal physiology and disease. The contributors review how the behavior of endothelial cells is controlled and discuss the regulatory roles of signaling molecules such as vascular endothelial growth factor, Notch, Wnt, VE-cadherin, and epsins. Vascular inflammation, immune cell trafficking, lipid metabolism, microRNAs, and the microbiome are also covered in the context of homeostasis and vasculature-related pathological conditions.