Angiogenesis: In Vitro Systems

Volume 443
Herausgegeben:Cheresh, David A.

• Gebundenes Buch

Produktbeschreibung

Angiogenesis is the growth of new blood vessels and is an important natural process in the body. A healthy body maintains a perfect balance of angiogenesis modulators. In many serious disease states, however, the body loses control over antiogenesis. Diseases that are angiogensis-dependent result when blood vessels either grow excessively or insufficiently.

Produktdetails

• Methods in Enzymology Volume 443
• Verlag: Academic Press / Elsevier Science & Technology
• Artikelnr. des Verlages: S0076-6879(08)X0011-4
• Seitenzahl: 432
• Erscheinungstermin: 2. September 2008
• Englisch
• Abmessung: 237mm x 159mm x 28mm
• Gewicht: 780g
• ISBN-13: 9780123743152
• ISBN-10: 012374315X
• Artikelnr.: 23581187

Inhaltsangabe

Studying cell signaling pathways; Flow mediated signaling; Endothelial cell adhesion and migration on the ECM; EC sprouting assays; Lumen formation assays; Isolation and propagation of EC's or SMC's; Cell-based assays to screen anti-angiogenic agents (chemical approach; ES cell models of vascular network formation; Co-culture studies with EC plus other cell types; Aortic ring sprouting (multiple cell types present); Effects of hypoxia or hyperoxia; Vascular Proteomics; In vitro vascular barrier function; EC leukocyte interactions; ECM signaling to the vasculature; Vascular Integrin signaling; Mechanical Signaling in blood vessels; Vascular and neuronal patterning; Vascular growth factors and their signals; VEGF receptor signal transduction; Development and testing of monoclonal antibodies directed to angiogenic targets.