Angiosperm Systematics of Mahadebpur Upazila of Naogaon District, Bangladesh was carried out from December 2013 to June 2015. A total of 265 species belonging to 204 genera under 94 families were recorded. These comprise of 116 herbs, 71 trees, 48 shrubs, 30 climbers, belong to 94 families. Cucurbitaceae and Amaranthaceae are the largest family in Magnoliopsida represented by 13 species in each and in Liliopsida, Poaceae is the largest family with 9 species. Amaranthaceae, Asteraceae, Apocynaceae, Caesalpiniaceae, Convolvulaceae, Cucurbitaceae, Euphorbiaceae, Fabaceae, Moraceae, Malvaceae, Mimosaceae, Myrtaceae, Poaceae, Rutaceae and Solanaceae are the dominant families with high species diversity. For each species botanical name, local name, habit, habitat, flowering and fruiting time, plant population, Medicinal uses, voucher number and family were provided. Dichotomous key to the genera and species based on field characters are presented. Photographs of all species are also presented.