From molecular biology to clinical applications of selective receptor blockade, the present volume compiles the latest advances of this emerging field. Of particular importance is the attention given to the newly discovered AT 2 receptors, and the physiology and pathophysiology of angiotensin receptor subtypes. The book will provide clinicians treating cardiovascular disease and hypertension with a clearer understanding of this therapeutically important and complicated hormone.
From molecular biology to clinical applications of selective receptor blockade, the present volume compiles the latest advances of this emerging field. Of particular importance is the attention given to the newly discovered AT2 receptors, and the physiology and pathophysiology of angiotensin receptor subtypes. The book will provide clinicians treating cardiovascular disease and hypertension with a clearer understanding of this therapeutically important and complicated hormone.
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Inhaltsangabe
1 Angiotensin II Receptor: Molecular Cloning, Functions, and Regulation.- 2 Molecular Biology of Angiotensin II Receptors.- 3 Defining Angiotensin Receptor Subtypes.- 4 Medicinal Chemistry of Angiotensin II Antagonists.- 5 The Angiotensin II AT2 Receptor Subtype.- 6 Medicinal Chemistry of AT2 Receptors.- 7 Pharmacology of AT2 Receptors.- 8 Brain Angiotensin II Receptor Subtypes.- 9 Second Messengers for Brain Angiotensin Receptor Subtypes.- 10 Angiotensin Receptor Subtypes and Cerebral Blood Flow.- 11 Angiotensin II Receptor Subtypes and Growth.- 12 Inhibiting the Effects of Angiotensin II on Cardiovascular Hypertrophy in Experimental Hypertension.- 13 Inhibiting the Effects of Angiotensin on Cardiovascular Hypertrophy.- 14 Angiotensin Antagonists in Models of Heart Failure.- 15 Angiotensin II Receptor Antagonism in an Ovine Model of Heart Failure: Comparison with ACE and Renin Inhibition.- 16 Angiotensin Antagonists in Models of Heart Failure.- 17 Angiotensin Antagonists in Models of Hypertension.- 18 Angiotensin II Antagonism and Renal function.- 19 Angiotensin Receptors and Renal function.- 20 Clinical Application of Treatment with Angiotensin Receptor Antagonists.- 21 Angiotensin Receptor Stimulation of Transforming Growth Factor-? in Rat Skin and Wound Healing.- References.
1 Angiotensin II Receptor: Molecular Cloning, Functions, and Regulation.- 2 Molecular Biology of Angiotensin II Receptors.- 3 Defining Angiotensin Receptor Subtypes.- 4 Medicinal Chemistry of Angiotensin II Antagonists.- 5 The Angiotensin II AT2 Receptor Subtype.- 6 Medicinal Chemistry of AT2 Receptors.- 7 Pharmacology of AT2 Receptors.- 8 Brain Angiotensin II Receptor Subtypes.- 9 Second Messengers for Brain Angiotensin Receptor Subtypes.- 10 Angiotensin Receptor Subtypes and Cerebral Blood Flow.- 11 Angiotensin II Receptor Subtypes and Growth.- 12 Inhibiting the Effects of Angiotensin II on Cardiovascular Hypertrophy in Experimental Hypertension.- 13 Inhibiting the Effects of Angiotensin on Cardiovascular Hypertrophy.- 14 Angiotensin Antagonists in Models of Heart Failure.- 15 Angiotensin II Receptor Antagonism in an Ovine Model of Heart Failure: Comparison with ACE and Renin Inhibition.- 16 Angiotensin Antagonists in Models of Heart Failure.- 17 Angiotensin Antagonists in Models of Hypertension.- 18 Angiotensin II Antagonism and Renal function.- 19 Angiotensin Receptors and Renal function.- 20 Clinical Application of Treatment with Angiotensin Receptor Antagonists.- 21 Angiotensin Receptor Stimulation of Transforming Growth Factor-? in Rat Skin and Wound Healing.- References.
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