Business-to-business (B2B) e-commerce adoption has become a necessity for most small and medium-sized enterprises (SMEs), allowing them to gain and sustain competitive advantage in a dynamic competitive environment. Accepting the fact that B2B is adopted at different levels based on different resources leads to the acceptance that competitive advantage is gained and sustained on a level consistent with the level of adoption. This study employs quantitative method based on the positivism philosophy and deductive approach. A questionnaire survey technique was used to collect the data from the American and Egyptian manufacturing SMEs. Moreover, it used structural equation modelling with a sample of 320 and 260 manufacturing SMEs in the United States of America and Egypt respectively.