There is an increasing interest in Lime orange (Citrus aurantifolia) fruits consumption across the world because of its rich sources of Vitamin C, folate, dietary fiber, minerals and rich phytochemicals. Traditionally, the plant have been used in the treatment of cough, sore throat, constipation, headache and malaria. The plant also possesses antibacterial, anticancer, antiviral, anthelmintic, antioxidant and laxative properties. Lime orange fruit peels are often discarded as waste product but this work tried to evaluate the anthelmintic activities of the peels extracts to seek alternative source of anthelmintics for human and animal used since there is an increasing resistance to the currently available synthetic anthelmintics. This work revealed that the plant extract possessed a remarkable anthelmintic efficacy in both in vitro and in vivo studies. This serves as a baseline for further studies that will produce a highly effective anthelmintics from lime orange peels.