Anti-Fibrotic Drug Discovery

Herausgeber: Brenneman, Jehrod; Iyer, Malliga R

• Gebundenes Buch

Produktbeschreibung

Fibrosis is a condition with globally high unmet medical need, and as such is a highly active area of academic and pharmaceutical research covering multiple treatment targets, organs, tissues and therapeutic approaches. Anti-fibrotic Drug Discovery is a single source reference for the latest drug-discovery approaches to tackle fibrosis in various tissues, comprehensively covering recent success and future perspectives on emerging therapeutic intervention points. The book highlights significant pre-clinical and clinical drugs currently being developed globally for this disorder. This book is ideal for postgraduate students and researchers with an interest in anti-fibrotic drug discovery as well as clinicians specialising in liver, kidney, heart and lung disease, in which fibrosis plays a key role in pathology.

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Produktdetails

• Verlag: RSC Publishing
• Seitenzahl: 356
• Erscheinungstermin: 3. März 2020
• Englisch
• Abmessung: 234mm x 157mm x 25mm
• Gewicht: 726g
• ISBN-13: 9781788015103
• ISBN-10: 178801510X
• Artikelnr.: 54851421

Inhaltsangabe

TGFß Signaling
Targeting the av Integrins in Fibroproliferative Disease
Discovery, Structural Refinement and Therapeutic Potential of Farnesoid X Receptor Activators
Autotaxin Inhibitors in Fibrosis
Inhibition of LOXL2 and Other Lysyl Oxidase (Like) Enzymes: Intervention at the Core of Fibrotic Pathology
Targeting the Ubiquitin Proteasome System in Pulmonary Fibrosis
Galectin-3 Involvement in Fibrotic Diseases
Emerging Role of CXCR4 in Fibrosis
BH3 Mimetic Drugs for Anti-fibrotic Therapy
Intratumoral Fibrosis: Emerging Concepts and Therapeutic Opportunities
Targeting Fibroblasts in Fibrosis and Cancer