Antibacterial nanocomplexes coated on guided tissue regeneration (GTR) membranes is an innovative approach to enhance periodontal healing and tissue regeneration. These membranes, typically used to support the regeneration of lost periodontal tissues, can be improved by integrating nanocomplexes that possess antimicrobial properties. The incorporation of nanoparticles, such as silver, zinc oxide, or graphene, into the GTR membrane provides a dual function: mechanical support for tissue growth and a barrier against microbial infections.The antimicrobial coating not only prevents bacterial colonization but also reduces the risk of postoperative complications, leading to improved clinical outcomes. The nanocomplexes release antimicrobial agents in a controlled manner, ensuring sustained protection over time. Research has demonstrated that these modified membranes can enhance cell proliferation, differentiation, and overall tissue repair.Overall, antibacterial nanocomplex-coated GTR membranes represent a promising advancement in periodontal therapies, potentially improving patient outcomes by combining tissue regeneration with effective infection control.