Periodontitis is an infection-driven chronic inflammatory condition that leads to destruction of the attachment apparatus of the tooth where, the major etiological factor leading to the destruction is plaque. Plaque act as a reservoir for the complex subgingival microbiota. Therefore, an inference here could be drawn that with the overall reduction of micro-organism, disease progression could be halted. Periodontal therapy aims at restoring balanced periodontal health along with the compatible oral microbiota. Antibiotic treatment strategies in conjugation with proper mechanical biofilm disruption, eventually helps in maintaining the periodontal health by minimizing and eradicating subgingival periodontal-pathogens and thereby, improves the status of clinical outcomes of periodontal therapy.This publication henceforth, attempts to highlight the walk-on part of antibiotics in periodontal therapy.