Poor Prescribing patterns can greatly have a negative impact on patient care outcomes. With the inappropriate prescribing of antibiotics there tends tobe antibioticresistance, unnecessary expenditure on drugs, and increased risk of adverse reactions. The aim of this study was to assess antibiotic prescribing patterns at Matero level one hospital in the adult admission wards Lusaka, Zambia.A retrospective cross-sectional study was undertaken data was collected using one-year patients records and administration of questionnaires to prescribers. National treatment guidelines were utilized to measure rational use of drugs with due focus on antibiotics prescribing patterns. The collected data was analyzed using statistical packages for social science (SPSS) version 23 and reported as Frequencies and percentages.There was a deviation of (48.9%) from recommended standards of prescribing antibiotics henceforth Interventions aimed at improving the antibiotic prescribing patterns need to be implemented so as to prevent the inappropriate use of antibiotics and avoid further complications.