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This book consists of two major sections, except for the introductory chapter by two editors regarding anticoagulation for portal vein thrombosis in liver cirrhosis. The first section includes four chapters, which provide an overview of knowledge regarding the history, indications, and laboratory monitoring of anticoagulation and electrochemical anticoagulant methods. The second section also includes four chapters, which aim to summarize the current evidence regarding anticoagulation in various clinical scenarios, including COVID-19, peripheral artery diseases, iliofemoral deep vein thrombosis, and ambulatory cancer patients. These chapters are useful for guiding how to use anticoagulants in routine clinical practice, manage patients with thrombotic diseases by anticoagulants, and design future studies regarding anticoagulation.