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Seizure is a paroxysmal event due to abnormal, excessive, hypersynchronous discharges from an aggregate of central nervous system neurons. Zinc sulfate, carvedilol and amlodipine have anticonvulsant effects through blocking sodium, calcium, and neurotransmitter (glutamate) receptors, and through their action on excitatory and inhibitory neurotransmitter levels, ion levels and cellular oxidative stress.