Anticonvulsant activity of pentazocine and its probable mechanism - Panchaksharimath, Praveen;Devaru, Siddappa;Singh, Shailender
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Pentazocine, which is known to act as an agonist at kappa opioid receptors and a weak antagonist or a partial agonist at mu receptors has shown significant anticonvulsant activity in MES test and abolition of this anticonvulsant activity by high dose but not by low dose of Naloxone. The present study was designed to compare the anticonvulsant effect of Pentazocine with standard Sodium Valproate in albino rats. An attempt was also made to determine the possible opioid receptor mechanism involved.

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Produktbeschreibung
Pentazocine, which is known to act as an agonist at kappa opioid receptors and a weak antagonist or a partial agonist at mu receptors has shown significant anticonvulsant activity in MES test and abolition of this anticonvulsant activity by high dose but not by low dose of Naloxone. The present study was designed to compare the anticonvulsant effect of Pentazocine with standard Sodium Valproate in albino rats. An attempt was also made to determine the possible opioid receptor mechanism involved.
Autorenporträt
Dr.Praveen Panchaksharimath, Assistant Professor, Department of Pharmacology, Bangalore has four years of experience in teaching and research. Graduated in Medicine in 2002 and completed Post Graduation in Pharmacology in 2008 from J.J.M.Medical College, Davangere. Since then working in Bangalore Medical College and Research Institute, Bangalore.