The use of chemical drugs, in general, has harmful side effects for human health, so our study encourages to return to nature through the use of crude extracts in control of many diseases resulting from microorganisms. Obviously, the wide use of antibiotics in the treatment of bacterial infections has led to spread of resistant strains so we need to find a source of bioactive substances that could possess a broad spectrum of activity when it is combined with antibiotic to be able to resist the pathogenic microorganism.