Periodontal disease is a infectious disease causing inflammation of the supporting tissues of the teeth leading to progressive attachment loss and bone loss. Specific plaque hypothesis plays an important role in the specific bacteria causing periodontal disease. The goal of antimicrobials in treating periodontal disease is to eliminate or suppress the potential pathogens in the oral cavity.The chapters in this book emphasis on biofilm, Systemic antibiotics ,antiseptics,natural products, local drug delivery, and host modulating agents.This book is useful for under graduates, Post graduates and dental professionals.