Antioxidant Activity of Phenolic Compounds in Cell Culture Systems - Zwane, Eunice Nonhlanhla Refiloe
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ROS and their proven involvement in some human physiopathologies have drawn significant interest over the last few decades. Oxidative stress has been associated with many diseases such as cancers. The development of disease can be attributed to the oxidative alteration of molecules such as proteins, lipids, carbohydrates and nucleic acids by ROS. The human body has developed its own defence system to deal with oxidative stress, but certain external factors such as UVR may result in elevated cellular ROS concentrations, overwhelming the body s defence system thus leading to disease. To…mehr

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Produktbeschreibung
ROS and their proven involvement in some human physiopathologies have drawn significant interest over the last few decades. Oxidative stress has been associated with many diseases such as cancers. The development of disease can be attributed to the oxidative alteration of molecules such as proteins, lipids, carbohydrates and nucleic acids by ROS. The human body has developed its own defence system to deal with oxidative stress, but certain external factors such as UVR may result in elevated cellular ROS concentrations, overwhelming the body s defence system thus leading to disease. To neutralize this effect, exogenic antioxidants particularly polyphenols, may be helpful to counteract ROS by preventing oxidation caused by ROS. To assess the antioxidant capacity of selected phenols, polyphenolic compounds were successfully synthesized in this study through biocatalytic reactions using phenol oxidases, to produce natural polyphenols suggested to have higher antioxidant activity thantheir monomers. Production of natural antioxidants was significantly considered for eventual consumer satisfaction and world market success if putative antioxidant were to go market.
Autorenporträt
Eunice Zwane obtained her MSc degree in Chemical Engineering in 2010 at the University of Cape Town. Since then she has worked as manager at various companies, her specialization being on strategically collecting and analyzing data. She is currently pursuing a PhD degree which focuses on the sustainable development of biofuel in South Africa.