There are an enormous number of traditional drugs associated with a vast empirical knowledge concerning their clinical use, but lacking modern investigation. This area appears to be promising for the future development of novel therapeutic agents. Albizzia lebbeck known as sirisha is being used in traditional medicine. It is reported to possess anti-asthmatic and anti-anaphylactic, immunomodulatory, anti-inflammatory and anti-microbial activities. The present study is on the antioxidant activity of A. lebbeck and its role in the prevention of hepatotoxicity. A. lebbeck seems to be a promising plant in respect to its antioxidant potential and possibility of developing a dietary oral supplement containing this extract or its active principle.