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Migraine is a chronic disabling disease that affects 12% of the world's population. Have settled several mechanisms involved in migraine, especially those of trigeminal activation and neurogenic inflammation in meninges. New studies indicate that migraine is related to inflammation and peripheral vascular oxidative stress.The detection of markers of inflammation and oxidation in migraine is of relevance both for therapeutics and for elucidating the mechanisms involved in this disease.The use of antioxidant vitamins can help reverse the vascular inflammatory and pro-oxidative state by reversing the migraine process.