Free radicals and antioxidant therapy have attracted a great deal of attention in recent years . Antioxidants are being widely used in routine general practice. There is an increased interest in the role of free radical oxidative damage in human diseases along with an upsurge in research implies its potential in dental practice too. This book will emphasize on the role of oxidants to periodontal tissue damage and will focus in detail the role of antioxidants in minimizing the periodontal tissue destruction.