Holmes, Jr., Laurens (Nemours Healthcare System, Wilmington, Delawar

Applied Epigenomic Epidemiology Essentials

A Guide to Study Design and Conduct

• Broschiertes Buch

Produktbeschreibung

This applied clinical medicine and public health text introduces the fundamental concepts in epidemiological investigation and demonstrates how to integrate emerging research on epigenomics into practice.

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Produktdetails

• Verlag: Taylor & Francis Ltd
• Seitenzahl: 352
• Erscheinungstermin: 1. Dezember 2023
• Englisch
• Abmessung: 234mm x 156mm x 19mm
• Gewicht: 532g
• ISBN-13: 9780367556273
• ISBN-10: 0367556278
• Artikelnr.: 68713449

Autorenporträt

Laurens Holmes, Jr. is a specialist in Immunology and Infectious Disease as well as an expert in cancer epidemiology and biostatistical modeling. He is a major proponent of aberrant epigenomic modulations in disease incidence, morbidity, prognosis, mortality and survival; and a former Head of the Epidemiology Laboratory at the Nemours Center for Childhood Cancer Research, Wilmington; former clinical and translational science education and training director, Medical College of Wisconsin, Milwaukee; as well as a former Professor of Molecular Epidemiology and Clinical Trials at the University of Delaware, USA. Professor Holmes is currently the Director of the Graduate Public Health Program at Delaware State University, Dover, USA.

Inhaltsangabe

Part 1: Epidemiology and Epigenomic Epidemiology Contribution in Clinical
Medicine and Public Health. 1.Introductory Epigenomic Epidemiology: Basic
Concepts and Application. 2.Public Health, Epidemiology and Translational
Epigenomic Epidemiology Perspective. 3.Scientific Research Concept and
Application: Public Health, Clinical Medicine and Epigenomic Epidemiology
Studies. 4.Disease Ascertainment-Diagnostic and Screening Test.
5.Epigenomic Epidemiology: Disease Association, Etiology, Prognosis and
Outcomes. Part 2 Traditional and Modern Epidemiologic Designs 6.Measures of
Disease Occurrence and Effect or Association. 7.Ecologic Design.
8.Cross-Sectional Study Design (Non-experimental). 9.Case-Control
(Comparison/Non-Case) Design. 10.Cohort Designs: Prospective,
Retrospective, Ambi-directional. 11.Human Experimental Design-Clinical
Trials. 12.Epidemiologic Causal Inference: Causality Web, Meta-Analysis,
Quantitative Evidence Synthesis (QES). Part 3 Laboratory Techniques and
Epigenomic Mechanistic Process in Epidemiologic Principles, Concept and
Application. 13.Epigenomic Laboratory Procedures: Mechanistic Process and
Techniques. 14.Epigenomic Studies Perspective: Malignant Neoplasm,
Protastic Adenocarcinoma-Prostate Cancer CaP. 15.Pediatric Acute
Lymphoblastic Leukemia (ALL): Aberrant Epigenomic Modulation Surrogate.
16.Cardiovascular Disease (CVD) : DNA Methylation of Candidate Genes (ACE
II, IFN-¿, AGTR1, CKG, ADD1, SCNN1B and TLR2) in Essential Hypertension.