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This issue of Hand Clinics, guest edited by Dr. Kevin Chung, will discusses Applying evidence-based concepts in the treatment of distal radius fractures in the 21st century. Dr. Chung also serves as Consulting Editor for Hand Clinics. Topics in this issue will include: A critical assessment of validity for the most cited in distal radius fractures; Nuances of radiographic assessment of distal radius fractures to avoid missed fragments; How to treat distal radius fractures; How to measure outcomes of distal radius fractures; What is the evidence in treating distal radius fracture in the geriatric population; How to close reduce distal radius fracture and appropriate method of casting; K wire fixation of distal radius fractures, indication, technique and outcomes; Plate fixation of distal radius fracture; Strategies for specific reduction in high-energy distal radius fractures; Arthroscopy in distal radius fractures: indications and when to do it; Distal radius fracture and the distal radioulnar joint; Therapy after distal radius fracture treatment; and Complex regional pain syndrome and distal radius fracture.