Approach to the genetic study of epithelial ovarian cancer - García Aliaga, Ángeles
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Results and discussion of our genetic study of epithelial ovarian cancer. Ovarian cancer is the gynaecological cancer with the highest mortality rate, with high-grade serous ovarian cancer accounting for 75% of this pathology, characterised by its aggressive course and diagnosis in advanced stages. One of the inclusion criteria according to the Spanish Society of Medical Oncology for high-risk hereditary breast and ovarian cancer syndrome (HOCCOS) is the diagnosis of non-mucinous high-grade epithelial ovarian cancer. HOCCOS has an autosomal dominant inheritance pattern in cancer susceptibility…mehr

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Produktbeschreibung
Results and discussion of our genetic study of epithelial ovarian cancer. Ovarian cancer is the gynaecological cancer with the highest mortality rate, with high-grade serous ovarian cancer accounting for 75% of this pathology, characterised by its aggressive course and diagnosis in advanced stages. One of the inclusion criteria according to the Spanish Society of Medical Oncology for high-risk hereditary breast and ovarian cancer syndrome (HOCCOS) is the diagnosis of non-mucinous high-grade epithelial ovarian cancer. HOCCOS has an autosomal dominant inheritance pattern in cancer susceptibility genes. Historically, the risk of SCMOH has been mainly linked to germline mutations in BRCA1/2. However, it is now also associated with tumour suppressor genes involved in DNA repair. High-grade ovarian cancer is evidenced by being genetically unstable and approximately 50% of these tumours are deficient in DNA repair mechanisms through homologous recombination.
Autorenporträt
Dott.ssa Ángeles García Aliaga, laureata in Biochimica con un Master in Biologia Molecolare e Biotecnologia e un Master in Gestione Clinica, Qualità e Sicurezza del Paziente. Formazione sanitaria specialistica in Radiofarmacia e dottorato di ricerca in Oncologia traslazionale sul cancro ovarico ereditario.