Are herbal remedies effective in HIV infection is a PhD research project that investigated most popular 5 herbal centres with unscientific claim of HIV curative medicines in Nigeria. The identified potential effective herbal remedy was investigated further with more HIV patients after phytochemical analysis and toxicological profiles were done. The herbal remedy was safe to use (acute, sub-acute or chronic) alone or in combination with present orthodox anti-HIV drugs (HAART).This fantastic herbal remedy increased the patient well being when used alone or as complementary therapy with HAART.It possesses greater therapeutic effect when used alone however, combination with HAART complements each other in side-effect amelioration.