This collection of 11 chapters is devoted to a survey of artificial and reconsti tuted membrane systems. These are fundamental themes and areas of great current importance in membrane biochemistry. They also relate well to the founding concept of this series, namely, to present studies that progressively work toward and provide us with an "integrated view of the cell. " In this volume, it is the application of a wide range of physiochemical and biochemi cal techniques to the study of membrane lipids and proteins which serves to demonstrate the significant progress that has been made in this…mehr
This collection of 11 chapters is devoted to a survey of artificial and reconsti tuted membrane systems. These are fundamental themes and areas of great current importance in membrane biochemistry. They also relate well to the founding concept of this series, namely, to present studies that progressively work toward and provide us with an "integrated view of the cell. " In this volume, it is the application of a wide range of physiochemical and biochemi cal techniques to the study of membrane lipids and proteins which serves to demonstrate the significant progress that has been made in this field over the past 25 years. From the understanding of simplified artificial systems, it is hoped that it will ultimately be possible to gain a more accurate understanding of natural biological membranes, in all their diversity. This book is an appropriate successor to Volume 13 of the series, which deals with fluorescence studies on biological membranes. Indeed, the present chapter by LesleyDavenport and colleagues was originally due for inclusion in Volume 13, but has been held over for inclusion in this volume, where it integrates remarkably well with the other topics. The extremely varied and interesting contents of this volume are now briefly outlined. In Chapter I, Jacqueline A. Reynolds and Darrell R. McCaslin pres ent a pertinent survey of the interaction of detergents with membrane lipids and proteins, together with an assessment of the reconstitution process.Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
1 The Role of Detergents in Membrane Reconstruction.- 1. Introduction.- 2. The Membrane Environment.- 3. Detergents.- 4. Reconstitution.- 5. Some Concluding Comments.- 6. References.- 2 Membrane Lipid Phase Behavior and Lipid-Protein Interactions.- 1. Introduction.- 2. Polymorphism of Membrane Polar Lipids.- 3. Phase Bèhavior of Mixed Lipid Systems.- 4. Protein-Lipid Interactions.- 5. Conclusions.- 6. References.- 3 Reconstitution of Membrane Molecular Mechanisms in Bilayer Lipid Membranes and Patch-Clamp Bilayers.- 1. Introduction.- 2. Techniques for Formation and Characterization of Reconstituted Bilayers.- 3. Reconstitution of Membrane Molecular Mechanisms Related to Ion Transport and Excitability.- 4. Reconstitution of Synaptic Events.- 5. Reconstitution of Sensory Mechanisms.- 6. Physiological Processes in Nonexcitable Membranes.- 7. Concluding Remarks and Perspective.- 8. References.- 4 Fluorescence Studies of Membrane Dynamics and Heterogeneity.- 1. Introduction.- 2. Do Domains Exist?.- 3. What Are the Relaxation Times for Lipid Domains?.- 4. Future Trends.- 5. References.- 5 Membrane Fusion: Fusogenic Agents and Osmotic Forces.- 1. Introduction.- 2. Fusogenic Lipids.- 3. Fusion Induced by Polyethylene Glycol.- 4. Electrically Induced Cell Fusion.- 5. Molecular Models for Membrane Fusion.- 6. Virally Induced Membrane Fusion i.- 7. Exocytosis.- 8. References.- 6 Lectin-Carbohydrate Interactions in Model and Biological Membrane Systems.- 1. Introduction.- 2. Lectins: Abundance and Properties.- 3. Glycolipids and Glycoproteins: Biological Receptors for Lectins.- 4. Lectin-Carbohydrate Interactions in Model Systems.- 5. Lectin-Carbohydrate Interactions in Biological Systems.- 6. References.- 7 Energy-Transducing Complexes in Bacterial Respiratory Chains.- 1.Introduction.- 2. Electron Transfer Chain and Energy Coupling.- 3. Reconstitution into Liposomes.- 4. Cytochrome Oxidase.- 5. Cytochrome bc1 Complexes.- 6. NADH Dehydrogenases and Complex I.- 7. Energy-Transducing Components Other Than Complexes I-IV.- 8. Concluding Remarks and Outstanding Problems.- 9. References.- 8 Reconstitution of the High-Affinity Receptor for Immunoglobulin E.- 1. Introduction.- 2. Purification of the Receptor.- 3. Mechanisms of Action of the Receptor: Possible Functions to Reconstitute.- 4. Reconstitution Studies.- 5. Conclusions.- 6. References.- 9 Reconstitution of Acetylcholine Receptors into Planar Lipid Bilayers.- 1. Introduction.- 2. Technical Aspects of Acetylcholine-Receptor Reconstitution.- 3. Properties of Reconstituted Acetylcholine-Receptor Channels.- 4. Gating Models and Theoretical Aspects.- 5. Data from Other Experiments.- 6. Principal Requirements for a Functional Aeetylcholine-Receptor Channel.- 7. Summary and Conclusion.- 8. References.- 10 Liposomes as Carriers of Drugs: Observations on Vesicle Fate after Injection and Its Control.- 1. Introduction.- 2. Retention of Drugs by Liposomes in Contact with Blood.- 3. Circulation of Liposomes in the Blood.- 4. Distribution of Liposomes in Tissues.- 5. Conclusions.- 6. References.- 11 Reconstitution and Physiological Protein Translocation Processes.- 1. Introduction.- 2. Membrane Proteins and Protein Translocation Processes.- 3. Energy Dependence of Protein Translocation Processes.- 4. Translocation and Membrane-Anchoring Signals.- 5. Post-Translational Protein Translocation.- 6. Protein Translocation through or Insertion into Lipid Aggregates.- 7. General and Concluding Remarks.- 8. References.
1 The Role of Detergents in Membrane Reconstruction.- 1. Introduction.- 2. The Membrane Environment.- 3. Detergents.- 4. Reconstitution.- 5. Some Concluding Comments.- 6. References.- 2 Membrane Lipid Phase Behavior and Lipid-Protein Interactions.- 1. Introduction.- 2. Polymorphism of Membrane Polar Lipids.- 3. Phase Bèhavior of Mixed Lipid Systems.- 4. Protein-Lipid Interactions.- 5. Conclusions.- 6. References.- 3 Reconstitution of Membrane Molecular Mechanisms in Bilayer Lipid Membranes and Patch-Clamp Bilayers.- 1. Introduction.- 2. Techniques for Formation and Characterization of Reconstituted Bilayers.- 3. Reconstitution of Membrane Molecular Mechanisms Related to Ion Transport and Excitability.- 4. Reconstitution of Synaptic Events.- 5. Reconstitution of Sensory Mechanisms.- 6. Physiological Processes in Nonexcitable Membranes.- 7. Concluding Remarks and Perspective.- 8. References.- 4 Fluorescence Studies of Membrane Dynamics and Heterogeneity.- 1. Introduction.- 2. Do Domains Exist?.- 3. What Are the Relaxation Times for Lipid Domains?.- 4. Future Trends.- 5. References.- 5 Membrane Fusion: Fusogenic Agents and Osmotic Forces.- 1. Introduction.- 2. Fusogenic Lipids.- 3. Fusion Induced by Polyethylene Glycol.- 4. Electrically Induced Cell Fusion.- 5. Molecular Models for Membrane Fusion.- 6. Virally Induced Membrane Fusion i.- 7. Exocytosis.- 8. References.- 6 Lectin-Carbohydrate Interactions in Model and Biological Membrane Systems.- 1. Introduction.- 2. Lectins: Abundance and Properties.- 3. Glycolipids and Glycoproteins: Biological Receptors for Lectins.- 4. Lectin-Carbohydrate Interactions in Model Systems.- 5. Lectin-Carbohydrate Interactions in Biological Systems.- 6. References.- 7 Energy-Transducing Complexes in Bacterial Respiratory Chains.- 1.Introduction.- 2. Electron Transfer Chain and Energy Coupling.- 3. Reconstitution into Liposomes.- 4. Cytochrome Oxidase.- 5. Cytochrome bc1 Complexes.- 6. NADH Dehydrogenases and Complex I.- 7. Energy-Transducing Components Other Than Complexes I-IV.- 8. Concluding Remarks and Outstanding Problems.- 9. References.- 8 Reconstitution of the High-Affinity Receptor for Immunoglobulin E.- 1. Introduction.- 2. Purification of the Receptor.- 3. Mechanisms of Action of the Receptor: Possible Functions to Reconstitute.- 4. Reconstitution Studies.- 5. Conclusions.- 6. References.- 9 Reconstitution of Acetylcholine Receptors into Planar Lipid Bilayers.- 1. Introduction.- 2. Technical Aspects of Acetylcholine-Receptor Reconstitution.- 3. Properties of Reconstituted Acetylcholine-Receptor Channels.- 4. Gating Models and Theoretical Aspects.- 5. Data from Other Experiments.- 6. Principal Requirements for a Functional Aeetylcholine-Receptor Channel.- 7. Summary and Conclusion.- 8. References.- 10 Liposomes as Carriers of Drugs: Observations on Vesicle Fate after Injection and Its Control.- 1. Introduction.- 2. Retention of Drugs by Liposomes in Contact with Blood.- 3. Circulation of Liposomes in the Blood.- 4. Distribution of Liposomes in Tissues.- 5. Conclusions.- 6. References.- 11 Reconstitution and Physiological Protein Translocation Processes.- 1. Introduction.- 2. Membrane Proteins and Protein Translocation Processes.- 3. Energy Dependence of Protein Translocation Processes.- 4. Translocation and Membrane-Anchoring Signals.- 5. Post-Translational Protein Translocation.- 6. Protein Translocation through or Insertion into Lipid Aggregates.- 7. General and Concluding Remarks.- 8. References.
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