To Take Aspirin or Not To Take Aspirin in Liver Damage. Aspirin is used for a long period in patients with cardiovascular diseases as a platelets de-aggregating agent, arthritis as an anti-inflammatory agent, etc. So aspirin can damage different body organs like Liver, Kidneys etc. Aspirin could be liver friendly if it be taken in an optimal dose. This book has been told about an optimal dose of aspirin in patients with liver insufficiency.