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Ancient herbs in India had been the source of treatment for various diseases varying from minor diseases like cold and cough to very serious condition like cancer. This work throws light on basics of antimicrobial and hepatoprotective activity , the current treatment available, herbs having antimicrobial and hepatoprotective activity, the significance of herbal drugs in the antimicrobial and hepatoprotective activity. This type of literary works provide a new area of research to the upcoming researchers.