Oral health care for children with disabilities is a health care area that has received scant attention. Lack of access to dental services for this growing segment of our population is reaching critical levels and is a national dilemma. Oral health problems can be barriers to adequate oral care and subsequently affect their quality of life (QoL) negatively. Full-mouth rehabilitation (FMR) under general anesthesia (GA) is required to provide safe and effective dental treatment for special need children, especially when extensive and complex treatment is necessary. Measuring children's oral health-related quality of life (OHRQoL) enables to evaluate the child's oral health status and treatment efficiency. Because of limited studies that are available covering this issue in the Kingdom of Saudi Arabia (KSA), the aim of this study was to assess changes in OHRQoL among special need children before and 12 months after FMR under GA in Jeddah city.