Despite the numerous benefits of HIV- positive status disclosure, studies have shown that the rates of disclosure among developing world are notably lower ranging from 16.7% to 86% compared to rates reported from the developed world (42% to 100%) (WHO, 2004). This research was a cross sectional study designed to determine the proportion of people living with HIV/AIDS who have disclosed their HIV-positive status to their sexual partners/family members and the reasons for non-disclosure in the Tano North District. Systematic random sampling method was used to draw 228 PLWHA for the study. The data collection tool was a structured questionnaire. Cross tabulations were done to determine the relationship between specific outcome variables and their predictors of disclosure. Chi-square tests were calculated and p-values of less than 0.05 were accepted as being statistical significant for all associations. The findings revealed that the proportion of HIV positive status disclosure to sexual partner(s)/family members was between 49.9% to 51.9%. Almost half (49.1%), of all persons interviewed during the study who had tested positive for HIV failed to disclose their HIV status.