Assessment of the anti-mycobacterial activity of selected Congolese medicinal plants - Bongo Ngiala, Gedéon;Tuntufye, Huruma;Kazwala, Rudovick
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Tuberculosis is an infectious disease that kills nearly 3 million people annually worldwide. The emergence of multidrug resistant and lengthy therapy reduces the patient compliance which comprises control strategies. In this study, the leaves of T. ivorensis, C. procera, F. macrophylla, A. occidentale, Ficus spp. and Drepanoalpha were extracted with different solvents to assess the anti-mycobacterial activity against M. tuberculosis H37Rv and M. tuberculosis spp. on LJ medium and Middlebrook 7H10 agar. The growth determined the activity of extracts and these were screened for the presence of…mehr

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Produktbeschreibung
Tuberculosis is an infectious disease that kills nearly 3 million people annually worldwide. The emergence of multidrug resistant and lengthy therapy reduces the patient compliance which comprises control strategies. In this study, the leaves of T. ivorensis, C. procera, F. macrophylla, A. occidentale, Ficus spp. and Drepanoalpha were extracted with different solvents to assess the anti-mycobacterial activity against M. tuberculosis H37Rv and M. tuberculosis spp. on LJ medium and Middlebrook 7H10 agar. The growth determined the activity of extracts and these were screened for the presence of phytochemicals. These extracts were found to be active against mycobacteria culture strains in Middlebrook 7H10 agar than in LJ slants. The presence of phytochemicals like flavonoids, tannins, alkaloids known to be of medicinal relevance points out a possible source for anti-mycobacterial agents to address the problem of multidrug resistance. The in vitro findings of this study provided a partial support for the use of these plants in the management of various infectious diseases as lead to drug discovery and should be reiterated and recommended for the in vivo study using an animal model.
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Autorenporträt
Gédéon Bongo Ngiala est titulaire d'une maîtrise en microbiologie appliquée de l'Université d'Agriculture de Sokoine (SUA), Tanzanie depuis 2016. Assistant tutorial et chercheur au Département de biologie, Faculté des sciences, Univ. de Kinshasa (Kinshasa) et chercheur associé à l'Université de Gbadolité (Nord-Ubangi) en République démocratique du Congo.