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Schistosomiasis is endemic in seventy five countries affecting more than 200 million people mostly those living in rural and agricultural areas near the water reservoir. Schistosomiasis causes long-term illness and significant economic burden. The available evidence indicates that, urinary schistosomiasis are still highly endemic in Tanzania and cause significant morbidity. Mass drug administration using praziquantel, currently used as a key intervention measure, has not been successful in decreasing prevalence (persistent rate) of urinary schistosomiasis among school children at Ngaiti village in Manyoni district,Singida region. The study draws attention to the health hazards posed by urinary schistosomiasis among school children in the studied area. The urgent need for a decisive control intervention to stem this problem cannot be overemphasized.