Radka Snajdrova

Asymmetric Baeyer-Villiger Oxidations Using Biocatalysts.

Development and Application of 2nd Generation of Biocatalysts

• Broschiertes Buch

Produktbeschreibung

Chiral lactones are important building blocks in organic synthesis. A broad range of useful products are accessible via enantioselective Baeyer-Villiger oxidation of simple ketones. Such lactones can serve as versatile building blocks in natural product and bioactive compound synthesis.For the transformation of achiral ketones to chiral lactones, Baeyer-Villiger monooxygenases (BVMOs) were utilized, since these enzymes exhibit wide substrate specificity and high enantioselectivity. The advantage of this approach is that BVMOs can generate several chiral centers in a single biotransformation step. Various cofactor recycling options have also been considered during this study. As a direct consequence of this research, a metabolically independent biocatalyst was developed, which performs cofactor regeneration concomitantly with the oxygenation reaction. . Such a system is very attractive for industrial applications as operational costs are dramatically reduced due to the absence forthe requirement of co-factor recycling.

Produktdetails

• Verlag: VDM Verlag Dr. Müller
• Seitenzahl: 288
• Englisch
• ISBN-13: 9783639192650
• ISBN-10: 3639192656
• Artikelnr.: 27006765

Autorenporträt

Radka Snajdrova studied Biochemistry at the Institute of Chemical Technology Prague. As a part of joint PhD program she carried out research at the Vienna University of Technology. Then she received Erwin-Schrödinger fellowship for postdoctoral stay at York University, UK. Currently, she holds faculty position at Greifswald University, Germany.