ATORVASTATIN SELF-EMULSIFIED TABLETS FORMULATION AND EVALUATION - Biswal, Prasanta Kumar;Sahu, Prafulla Kumar
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Due to poor drug solubility and absorption, many drug candidates fall short of expectations. Self-emulsifying drug delivery methods increase the solubility and bioavailability of poorly soluble medications. When SEDDS are added to an aqueous phase and gently mixed, fine oil-in-water emulsions form. SEDDS come in soft or hard gelatin capsules for oral administration and form fine, stable oil-in-water emulsions. SEDDS are primarily manufactured as liquid formulations, which have poor stability and mobility, low drug loading, a limited number of dosage form options, irreversible drug/excipient…mehr

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Produktbeschreibung
Due to poor drug solubility and absorption, many drug candidates fall short of expectations. Self-emulsifying drug delivery methods increase the solubility and bioavailability of poorly soluble medications. When SEDDS are added to an aqueous phase and gently mixed, fine oil-in-water emulsions form. SEDDS come in soft or hard gelatin capsules for oral administration and form fine, stable oil-in-water emulsions. SEDDS are primarily manufactured as liquid formulations, which have poor stability and mobility, low drug loading, a limited number of dosage form options, irreversible drug/excipient precipitation, and a high proportion (30-60%) of surfactants that might irritate the gastrointestinal system. Solid-SEDDS has been studied to avoid the problems of liquid SEDDS. The adsorption of liquid self-micro-emulsified formulations on solid carriers is one of the best ways to create free-flowing powders for compression into tablet dosage form (SMET).
Autorenporträt
A Dra. Prasanta Kumar Biswal está actualmente a trabalhar como Professora e Chefe do Departamento de Farmácia, Gayatri College of Pharmacy, Sambalpur, Odisha, Índia.O Dr. Prafulla Kumar Sahu, Ph.D. está a trabalhar como Professor Principal cum na Faculdade de Farmácia, Universidade de Tecnologia e Gestão do Centurião, Campus de Bolangir.