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The main objective of this study was to examine the attitudes of Muslims in Lagos State to HIV and AIDS, including their level of awareness and enlightenment, capacity to show love, care and support for people living with HIV (PLWH), People Affected by AIDS (PABA), Muslim Orphans and Vulnerable Children (OVC) and common measures at stemming this tide such as global knowledge on safe sexual and productive health behavior among Muslim communities in Lagos State. This is in recognition of a gap in knowledge and research in the area of HIV and AIDS prevalence, management and impact among Muslims in Lagos State, Nigeria. The study is significant because it is an exposition of HIV and AIDS to many Muslim individuals in Lagos State, which also helps in understanding several other related issues connected with this deadly disease. Its examination of the Islamic moral implications of HIV and AIDS to Lagos Muslims, also makes the work very inevitable.