Consanguineous marriages are in practice as a part and parcel of tradition in various areas of Globe. The opinions and practice vary widely across the world in few communities it is considered as ideal. All these are the reasons for practice of consanguineous marriages meanwhile Acharya Charaka in Atulyagotriya Sharira Adhyaya states that the marriage should be practiced in a different clan because marrying in the same clan is considered as Adharma which must be avoided. As per modern science, genetics states that this system of marrying in same clan has to be prohibited to maintain the social order uphold religious morality and last but not the least to safeguard the creation of fit offspring. Many studies have been conducted on the outcome of consanguineous marriages and outcome of these states that it ends up in various genetic abnormalities like mental retardation, diabetes, deafness, blindness etc., which decreases the social and economic state of nation.