Anti-TPO is present in the serum of almost all Hashimoto thyroid patients, in more than 70% of those with Graves disease, and, in a variable degree, in patients with autoimmune non-oxidizing disease and some normal subjects. There is a good correlation between the degree of thyroid infiltration of the thyroid gland and the anti-TPO titre. Postpartum thyroiditis, usually a temporary disorder, occurs at high frequency in women who have anti-TPO presence. The presence of anti-TPO and anti-Tg, is a clinically useful marker for the determination of autoimmune thyroid disease and for the detection of a basic autoimmune prophylaxis in the thyroid. The purpose of this study is to identify the correlation between different autoimmune thyroid diseases and the presence of anti-TPO and anti-TG antibodies. Evaluation of thyroid dysfunction in patients of this condition in the population of Gjirokastra Region based on the presence of thyroid autoantibodies and other specific thyroiditis examinations.