Autophagic tumor stroma model of cancer
Epithelium, Oxidative stress, Stromal cell, Connective tissue, Reactive oxygen species
Herausgegeben: Avery, Iustinus Tim
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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. The autophagic tumor stroma model of cancer proposes that epithelial cancer cells use oxidative stress as a weapon to extract recycled nutrients from adjacent stromal fibroblasts (i.e., connective tissue cells). The theory posits that oxidative stress in cancer associated fibroblasts forces these cells to eat themselves, by a process called autophagy or self-cannibalism . The resulting recycled nutrients, derived from catabolism in the tumor stroma, are then used to p...
Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. The autophagic tumor stroma model of cancer proposes that epithelial cancer cells use oxidative stress as a weapon to extract recycled nutrients from adjacent stromal fibroblasts (i.e., connective tissue cells). The theory posits that oxidative stress in cancer associated fibroblasts forces these cells to eat themselves, by a process called autophagy or self-cannibalism . The resulting recycled nutrients, derived from catabolism in the tumor stroma, are then used to power the anabolic growth of cancer cells. Thus, cancer is a disease of energy imbalance , resulting from the vectorial and unilateral transfer of energy-rich nutrients from the tumor stroma to cancer cells. (This explains the phenomenon of cancer-associated cachexia (systemic wasting), in which patients with advanced cancer cannot maintain their normal body weight).
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