Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

Herausgegeben:Hayat, M. A.

• Gebundenes Buch

Produktbeschreibung

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is an eleven volume series that discusses in detail all aspects of autophagy machinery in the context of health, cancer, and other pathologies. Autophagy maintains homeostasis during starvation or stress conditions by balancing the synthesis of cellular components and their deregulation by autophagy. This series discusses the characterization of autophagosome-enriched vaccines and its efficacy in cancer immunotherapy.

Autophagy serves to maintain healthy cells, tissues, and organs, but also promotes cancer survival and growth of established tumors. Impaired or deregulated autophagy can also contribute to disease pathogenesis. Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward-thinking, these books offer a valuable guide to cellular processes while also inciting researchers to explore their potentially important connections.

Produktdetails

• Verlag: Academic Press
• Artikelnr. des Verlages: C2015-0-04141-7
• Erscheinungstermin: 25. Januar 2017
• Englisch
• Abmessung: 27mm x 201mm x 242mm
• Gewicht: 1062g
• ISBN-13: 9780128054208
• ISBN-10: 0128054204
• Artikelnr.: 47148517

Autorenporträt

Dr. Hayat has published extensively in the fields of microscopy, cytology, immunohistochemistry, immunocytochemistry, and antigen retrieval methods. He is Distinguished Professor, Department of Biological Sciences, Kean University, Union, New Jersey, USA.

Inhaltsangabe

Part I: Molecular Mechanisms 1. Overview of Autophagy 2. Methods for Measuring Autophagosome Flux-Impact and Relevance 3. Loss of Pigment Epithelial Cells Is Prevented by Autophagy 4. Role of Autophagy Inhibition in Regulating Hepatic Lipid Metabolism: Molecular Cross Talk Between Proteasome Activator REG? and SirT1 Signaling 5. Role of Autophagy in Regulating Cyclin A2 Degradation: Live-Cell Imaging 6. Roles of Rab-GAPs in Regulating Autophagy 7. The Role of Histone Deacetylase Inhibition in the Accumulation and Stability of Disease-Related Proteins 8. The Role of Atg9 in Yeast Autophagy

Part II: Role in Disease 9. Methods for Measuring Autophagy Levels in Disease 10. Regulation of the DNA Damage Response by Autophagy 11. Autophagy and Cancer 12. ULK1 Can Suppress or Promote Tumor Growth Under Different Conditions 13. X-Box-Binding Protein 1 Splicing Induces an Autophagic Response in Endothelial Cells: Molecular Mechanisms in ECs and Atherosclerosis 14. Small Molecule-Mediated Simultaneous Induction of Apoptosis and Autophagy 15. Intestinal Autophagy Defends Against Salmonella Infection 16. Autophagy and LC3-Associated Phagocytosis Mediate the Innate Immune Response