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Azole Derivatives as an Protein Tyrosin Kinase Inhibitors - Agrawal, Yogesh;Agrawal, Mona
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  • Broschiertes Buch

In the present book The Azoles Derivatives as Potent Protein Tyrosine Kinase Inhibitor , we provide an exhaustive literature regarding the Antiproliferative potential of Protein Tyrosine Kinase Inhibitors. Various analogous of imatinib were Designed and prepared by replacing the pyrimidine ring of imatinib with an azole nucleous like Imidazole, Benzimidazole and Benzthiazole. Imatinib an well reputed anti-cancer agent contain pyrimidine ring, composition of various biological enzymes and proteins of normal cell, as analogous of ATP inhibit the natural cell protein Kinase, hence responsible for…mehr

Produktbeschreibung
In the present book The Azoles Derivatives as Potent Protein Tyrosine Kinase Inhibitor , we provide an exhaustive literature regarding the Antiproliferative potential of Protein Tyrosine Kinase Inhibitors. Various analogous of imatinib were Designed and prepared by replacing the pyrimidine ring of imatinib with an azole nucleous like Imidazole, Benzimidazole and Benzthiazole. Imatinib an well reputed anti-cancer agent contain pyrimidine ring, composition of various biological enzymes and proteins of normal cell, as analogous of ATP inhibit the natural cell protein Kinase, hence responsible for non-specificity in activity with low selectivity and side effects. BMS-33197 an excellent Bcr-Abl kinase inhibitor contain an oxazole nucleolus responsible for its activity so various imatinib analogous were prepared isosterically.
Autorenporträt
Yogesh P. Agrawal studied at School of Pharmaceutical Sciences,UTD, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Bhopal, India and obtained her Master s degree in the field of Pharmaceutical Chemistry in 2007. Currently an Assistant Professor in Department of Pharmaceutical Chemistry, Government College of Pharmacy, Ratnagiri, Mumbai University, India