B Cell Receptor Signaling

Herausgegeben:Kurosaki, Tomohiro; Wienands, Jürgen

• Gebundenes Buch

Produktbeschreibung

Thisvolume details our current understanding of the architecture and signalingcapabilities of the B cell antigen receptor (BCR) in health and disease. Thefirst chapters review new insights into the assembly of BCR components andtheir organization on the cell surface. Subsequent contributions focus on themolecular interactions that connect the BCR with major intracellular signalingpathways such as Ca2+ mobilization, membrane phospholipidmetabolism, nuclear translocation of NF-kB orthe activation of Bruton's Tyrosine Kinase and MAP kinases. These elementsorchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamicsfor antigen internalization. Furthermore, a key mechanism of how B cellsremember their cognate antigen is discussed in detail. Altogether, the discoveriespresented provide a better understanding of B cell biology and help to explainsome B cell-mediated pathogenicities, like autoimmune phenomena or theformation of B cell tumors, whilealso paving the way for eventually combating thesediseases.

Produktdetails

• Current Topics in Microbiology and Immunology 393
• Verlag: Biotechnology and Biological Sciences Research Council / Springer / Springer International Publishin
• Artikelnr. des Verlages: 978-3-319-26131-7
• 1st ed. 2016
• Seitenzahl: 240
• Erscheinungstermin: 6. Januar 2016
• Englisch
• Abmessung: 241mm x 160mm x 19mm
• Gewicht: 473g
• ISBN-13: 9783319261317
• ISBN-10: 3319261312
• Artikelnr.: 43828375

Autorenporträt

Tomohiro Kurosaki, MD, PhD, is a professor at WPI Immunology Frontier Research Center at Osaka University, Japan Jürgen Wienands, PhD, is a professor of Cellular and Molecular Immunology at the University of Göttingen, Germany

Inhaltsangabe

Assembly and function of the precursor B-cell receptor.- Receptor Dissociation and B cell activation.- Molecular mechanisms of B cell antigen gathering and endocytosis.- BTK signaling in B cell differentiation and autoimmunity.- The memory function of the B cell antigen receptor.- PI3K signaling in normal B cells and chronic lymphocytic leukemia (CLL).- Role of Calcium Signaling in B Cell Activation and Biolog.- Roles of the NF-kappaB pathway in B-lymphocyte biology.- MAP kinase cascades in antigen receptor signaling and physiology.