B cell specificity and pattern in primary Sjögren's syndrome - Aqrawi, Lara A.
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Sjögren's syndrome (SS) is a chronic autoimmune disease characterised by focal inflammation of the salivary and lacrimal glands, resulting in the common symptoms of dry eyes and dry mouth. Here, mononuclear cells, including B cells, infiltrate the glands, leading to their dysfunction and later destruction. Another distinctive feature is the systemic production of autoantibodies that results from the activation of B cells into antibody secreting plasma cells. Hence, although the etiology of SS remains unclear, B cells do play an important part in the pathogenesis of this disease. In this…mehr

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Produktbeschreibung
Sjögren's syndrome (SS) is a chronic autoimmune disease characterised by focal inflammation of the salivary and lacrimal glands, resulting in the common symptoms of dry eyes and dry mouth. Here, mononuclear cells, including B cells, infiltrate the glands, leading to their dysfunction and later destruction. Another distinctive feature is the systemic production of autoantibodies that results from the activation of B cells into antibody secreting plasma cells. Hence, although the etiology of SS remains unclear, B cells do play an important part in the pathogenesis of this disease. In this doctoral work we explore the immunological process, while addressing the concept of B cell specificity and pattern in primary SS (pSS). We consider both the general and the autoantigen-specific B cell pattern in the peripheral blood and the salivary glands of patients with pSS, and also account for the expression pattern of the Ro52 autoantigen. Furthermore, we explore a congenic NOD mouse strain,namely NOD.B10.H2b, in order to characterise the plasma cell compartment in the parotid and submandibular salivary glands and in the bone marrow.
Autorenporträt
Dr. Lara A. Aqrawi is an immunologist of Iraqi ethnicity, and has completed her PhD in autoimmunity and Sjögren¿s syndrome. She is currently a researcher in the same field at the University of Bergen, Bergen Norway in collaboration with the Karolinska Institute, Stockholm, Sweden. Lara is also a post doctor at the University of Oslo, Oslo Norway.