Janna Budarina

Baciullus cereus haemolysin II: illusion or reality?

Gene cloning, regulation of expression, product identification

• Broschiertes Buch

Produktbeschreibung

Bacterial toxins are rightly regarded as essential pathogenicity factors in the bacteria that produce them. Hence the traditional sustained interest in the study of these substances. Bacillus cereus, the closest relative of the anthrax pathogen, B. antracis, produces a wide range of toxins. However, their range is far from being fully understood. Thus, one of the hemolytic toxins of B. cereus, hemolysin II, eluded researchers for decades. The existence of this hemolysin was disputed, its activity attributed to other proteins. Clarity in this matter was achieved when a new gene hlyII was cloned from the B. cereus genome, the protein product of which was identified as haemolysin II. On the basis of amino acid sequence analysis, haemolysin II belongs to the family of beta-folded pore-forming oligomeric cytolysins. The expression of hlyII is controlled by the protein product of the first described gene hlyIIR, which is capable of acting as both a positive and negative regulator of hlyII. The ability to produce haemolysin II is a strain-specific property of B. cereus and B. thuringiensis.

Produktdetails

• Verlag: Our Knowledge Publishing
• Seitenzahl: 148
• Erscheinungstermin: 12. August 2021
• Englisch
• Abmessung: 220mm x 150mm x 9mm
• Gewicht: 238g
• ISBN-13: 9786203544190
• ISBN-10: 6203544191
• Artikelnr.: 62423696

Autorenporträt

Budarina Zhanna Igorevna, doctora en biología, defendió su tesis en genética en el Instituto Estatal de Investigación Genética de Moscú, investigadora del Laboratorio de Microbiología Molecular del Instituto de Bioquímica Skryabin de la Academia de Ciencias de Rusia. Trabajo científico asociado al estudio de los mecanismos de regulación de los genes de las toxinas bacterianas.