Endlich ein Buch, das sich ausschließlich mit Struktur und physiologischer Funktion von Porinen beschäftigt! Gut nachvollziehbar werden hier Ergebnisse der biophysikalischen Grundlagenforschung mit Resultaten aus Zellstudien (in vivo und in vitro) zu einem anschaulichen Gesamtbild der grundlegenden Rolle der Porine für das Funktionieren von Zellen verknüpft. Unentbehrlich für einschlägig interessierte Biochemiker, Mikrobiologen, Biotechnologen und Physiologen.
Endlich ein Buch, das sich ausschließlich mit Struktur und physiologischer Funktion von Porinen beschäftigt! Gut nachvollziehbar werden hier Ergebnisse der biophysikalischen Grundlagenforschung mit Resultaten aus Zellstudien (in vivo und in vitro) zu einem anschaulichen Gesamtbild der grundlegenden Rolle der Porine für das Funktionieren von Zellen verknüpft. Unentbehrlich für einschlägig interessierte Biochemiker, Mikrobiologen, Biotechnologen und Physiologen.
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Autorenporträt
Roland Benz (born 1943) studied Mathematics, Chemistry and Physics at the University of Würzburg (Germany) before joining the group of Peter Läuger at Konstanz University, where he obtained his PhD in Biology and his habilitation in Biophysics. Recipient of a Heisenberg Fellowship of the German Research Society (DFG), he was a Visiting Professor at the State University of New York in 1980 and again in 1982, and at the University of British Columbia in Vancouver in 1984. Since 1986 he is full Professor of Biotechnology at the University of Würzburg. His research is centered on the molecular basis of membrane transport in microorganisms and higher organisms, with a special interest into pore-forming peptides and proteins.
Inhaltsangabe
Regulation of Porin Gene Expression by the Two-Component Regulatory System EnvZ/OmpR The Structures of General Porins Role of bacterial porins in antibiotic susceptibility of gram-negative bacteria Porins of the Outer Membrane of Pseudomonas aeruginosa Regulation of Bacterial Porin Function Reconstitution of General Diffusion Pores from Bacterial Outer Membranes OmpA/OprF: Slow Porins or Channels Produced by Alternative Folding of Outer Membrane Proteins Drug Efflux and Protein Export through Channel-tunnels Structure-Function Relationships in Sugar-Specific Porins Role of the Carbohydrate-Specific Maltoporin in Substrate Uptake Functional Reconstitution of Specific Porins Energy-Coupled Outer Membrane Iron Transporters Structural and Functional Aspects of the Vitamin B12 Receptor BtuB Structure and Function of Mitochondrial Porins Mitochondrial Porins in Mammals: Insights Into Functional Roles From Mutant Mice and Cells Gene Family Expression and Multitopological Localization of Eukaryotic Porin/VDAC Function of the Outer Mitochondrial Membrane Pore (VDAC) in Intracellular Signalling
Regulation of Porin Gene Expression by the Two-Component Regulatory System EnvZ/OmpR The Structures of General Porins Role of bacterial porins in antibiotic susceptibility of gram-negative bacteria Porins of the Outer Membrane of Pseudomonas aeruginosa Regulation of Bacterial Porin Function Reconstitution of General Diffusion Pores from Bacterial Outer Membranes OmpA/OprF: Slow Porins or Channels Produced by Alternative Folding of Outer Membrane Proteins Drug Efflux and Protein Export through Channel-tunnels Structure-Function Relationships in Sugar-Specific Porins Role of the Carbohydrate-Specific Maltoporin in Substrate Uptake Functional Reconstitution of Specific Porins Energy-Coupled Outer Membrane Iron Transporters Structural and Functional Aspects of the Vitamin B12 Receptor BtuB Structure and Function of Mitochondrial Porins Mitochondrial Porins in Mammals: Insights Into Functional Roles From Mutant Mice and Cells Gene Family Expression and Multitopological Localization of Eukaryotic Porin/VDAC Function of the Outer Mitochondrial Membrane Pore (VDAC) in Intracellular Signalling
Rezensionen
"This excellent book should be present in all laboratories ... In addition, it is suitable for advanced students in microbiology and molecular biology. The information is extremely up-to-date and is supported by high-quality and highly original graphics." International Microbiology "...a scholarly research monograph on the biophysical aspects of porins...recommended for molecular and structural biologists working with porin proteins and academic libraries." E-STREAMS
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