Bacterial Resistance to Antimicrobials

Herausgeber: Lewis, Kim; Wax, Richard G.; Salyers, Abigail A.

• Gebundenes Buch

Produktbeschreibung

The enormous genetic flexibility of bacteria jeopardizes the usefulness of currently available antibiotics, and requires new approaches to antibiotic discovery and development. Antimicrobial resistance can be acquired in a short time frame, both by genetic mutation and by direct transfer of resistance genes across genus and species boundaries. Understanding mechanisms of resistance is crucial to the future of antimicrobial therapy. Extensively revised, with contributions from international leaders in their fields, Bacterial Resistance to Antimicrobials, Second Edition blends scientific and practical approaches to the social, economic, and medical issues related to this growing problem. The book begins with a history of antimicrobial agents and bacterial resistance, and outlines the forces that contributed to the abuse of antibiotics and precipitated the current crisis. It goes on to describe what is known about the ecology of antibiotic resistant bacteria and reveals the inadequacies in our understanding. Emphasizing public health aspects, the editors stress that significant progress will be made only by addressing the problem only as a public, worldwide, problem. Chapters on resistance mechanisms describe the latest findings on what makes different groups of bacteria susceptible or resistant to antibiotics. They reveal the staggering diversity of bacteria and the need for a foundational understanding that will stimulate development of antibiotics capable of avoiding resistance mechanisms. Examining the success and limitations of complementary approaches, such as combining ß-lactam antibiotics with ß-lactamase inhibitors, the book brings together information on resistance mechanisms in different groups of bacteria to help future efforts to more effectively develop and deploy antimicrobial therapies.

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Produktdetails

• Verlag: CRC Press
• 2. Auflage
• Seitenzahl: 446
• Erscheinungstermin: 5. Dezember 2007
• Englisch
• Abmessung: 240mm x 161mm x 28mm
• Gewicht: 833g
• ISBN-13: 9780849391903
• ISBN-10: 0849391903
• Artikelnr.: 23595725

Autorenporträt

Richard G. Wax, Kim Lewis, Abigail A. Salyers, Harry Taber

Inhaltsangabe

Microbial Drug Resistance: A Historical Perspective. Ecology of Antibiotic
Resistance Genes. Global Response Systems that Confer Resistance. Multidrug
Efflux Pumps: Structure, Efflux, and Inhibition. Mechanisms of
Aminoglycoside Antibiotic Resistance. Resistance to ß-Lactam Antibiotics
Mediated by ß-Lactamases. Target Modification as a Mechanism of
Antimicrobial Resistance. Antibiotic Permeability. Genetic Methods for
Detecting Bacterial Resistance Genes. The Evolution and Epidemiology of
Antibiotic Resistant Pneumococci. Antimicrobial Resistance in the
Enterococcus. Methicillin Resistance in Staphylococcus aureus. Mechanism of
Drug Resistance in Mycobacterium tuberculosis. Antibiotic Resistance in
Enterobacteria. Resistance as a Worldwide Problem. Public Health Responses
to Antimicrobial Resistance in Outpatient and Inpatient Settings.
Antibacterial Drug Discovery in the 21st Century.