Bacterial Strain Improvement by Mutagenesis

Bacterial Strain Improvement by Mutagenesis

Isolation, Characterization and Improvement of Bacterial Strains for Enhanced Production of Penicillin Acylase

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Bacterial enzymes such as penicillin acylases are used for biosynthesis of betalactam antibiotics. The present study highlights the importance of manipulation of microbiological media and methods for isolation and characterization of bacterial strains having potential for penicillin acylases. Simple approach has been adopted for developing mutants with enhanced production of penicillin acylase. Bacterial strains collected from different ecological niches have unique properties and manifests diverse levels of enzyme activity. The high diversity in the natural population demonstrates that broad ...