Bacteriophage therapy for Enterococcus faecalis organism - Oli, Ajaykumar;Kelmani, Chandrankanth
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The study revealed the prevalence of multidrug-resistant strains of E.faecalis. Presently, the problem of vancomycin- resistant enterococci (VRE) may not be very high in India as seen in our clinical isolates. The potential of phage has been the subject of several recent reviews and the present study strengthens the view that phage therapy is worth exploring. We resolute our efforts on MDR VRE because we predicted that positive results would reveal the prospective of this form of therapy in situations where few substitutes and alternatives are available. The present investigation is an attempt…mehr

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Produktbeschreibung
The study revealed the prevalence of multidrug-resistant strains of E.faecalis. Presently, the problem of vancomycin- resistant enterococci (VRE) may not be very high in India as seen in our clinical isolates. The potential of phage has been the subject of several recent reviews and the present study strengthens the view that phage therapy is worth exploring. We resolute our efforts on MDR VRE because we predicted that positive results would reveal the prospective of this form of therapy in situations where few substitutes and alternatives are available. The present investigation is an attempt made to develop an alternative to conventional drugs. One possible option is to use bacteriophage as an antimicrobial agent. Their use as an agents of sanitation or disinfectants for application in controlling clinical and nosocomial infections. The significance of our study is the dose of 3x1010 PFU/ml showed in the increased efficiency of the phage GACP against VREF122 even though having smaller genome.Hence ,we conclude that,our phage GACP showed more efficient than earlier reports.
Autorenporträt
Awarded the Ph.D degree in the subject Biotechnology from Gulbarga University gulbarga in the year 2013. Worked on Major Research Project grant from UGC New Delhi, government of India on MRSA. Awarded the CSIR-SRF 2012.