Tomato (Solanum lycopersicum, L., 2 n = 24) is the most important popular vegetable, grown all over the world, tomato is used in all human recipes, food, and other health care products. Most of tomato plantations is subject to be attacked by many virulence pathogens at any of production stage, from other side the cost of controlling these virulence pathogens consuming huge money and safety is not guaranteed at this case. The use of natural defense become more safe for human being and animals. So that, breeders are seeking to find a natural solution from plant itself, through using natural products, that natural compounds are self-defense products affecting or deactivating the pathogen activity in case of attacking plants.