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The Guests Editors have assembled expert authors to present clinical reviews on the current knowledge and best practices for high-risk pregnancies. Authors are writing on Genetics: update on prenatal screening and diagnosis; Screening for congenital heart disease; What you need to know when managing twins; Short cervix dilemma; preterm labor: approach to decreasing complications of prematurity; Optimizing outcomes for the growth-restricted fetus; Preeclampsia: short- and long-term implications; pregnancy risk associated with obesity; prevention of first cesarean delivery, and diagnosis and management of placenta accreta.