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Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality worldwide, and represents a huge and growing economic and social burden. COPD is a multi-factorial disorder caused by environmental determinants and genetic risk factors. The beta2-adrenergic receptor (_2-AR) mediates various physiologic responses of the airways. Alterations in the ADRB2 gene have a significant physiologic role in regulating responses to exogenous _2-agonists. Understanding the genetic predisposition of COPD is essential to develop personalized treatment regimens.

Produktbeschreibung
Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality worldwide, and represents a huge and growing economic and social burden. COPD is a multi-factorial disorder caused by environmental determinants and genetic risk factors. The beta2-adrenergic receptor (_2-AR) mediates various physiologic responses of the airways. Alterations in the ADRB2 gene have a significant physiologic role in regulating responses to exogenous _2-agonists. Understanding the genetic predisposition of COPD is essential to develop personalized treatment regimens.
Autorenporträt
Mohammad H Hussein have master degree in Chest Diseases, Faculty of Medicine, Cairo University, Egypt. Over past 10 years he has concerned about genotype-phenotype correlation in cardiopulmonary diseases.