G. Paumgartner / U. Beuers (eds.)

Bile Acids in Liver Diseases

Herausgegeben:Paumgartner, G.; Beuers, U.

• Gebundenes Buch

Produktbeschreibung

Bile acid research has attracted increasing attention from both basic scientists and clinical hepatologists over the last decade. Experimental studies have expanded our knowledge of the role of bile acids in liver disease, and well-designed clinical trials have documented beneficial effects of bile acid treatment for a number of hepatobiliary diseases.
Bile Acids in Liver Diseases, the proceedings of an International Falk Workshop held in Munich, January 1995, provides insights into current concepts in bile acid chemistry, bile acid synthesis and metabolism, and transport of bile acids across the hepatocyte. The role of bile acids in bile formation, cholestasis and hepatotoxicity are discussed.
Finally, the book addresses experimental studies and hypotheses about the putative mechanisms of action of ursodeoxycholic acid in cholestatic liver diseases, and summarizes the clinical applications of bile acid treatment on the basis of controlled clinical trials.

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Produktdetails

• Falk Symposium 82b
• Verlag: Springer / Springer Netherlands
• Artikelnr. des Verlages: 978-0-7923-8891-3
• 1995
• Seitenzahl: 180
• Erscheinungstermin: 31. Dezember 1995
• Englisch
• Abmessung: 241mm x 160mm x 16mm
• Gewicht: 471g
• ISBN-13: 9780792388913
• ISBN-10: 0792388917
• Artikelnr.: 23117003

Inhaltsangabe

List of principal authors. Preface. Section I: Bile acid synthesis. 1.
Species differences in bile acid metabolism; A.F. Hofmann, et al. 2. Role
of alternative pathways of bile acid biosynthesis in liver disease; J.
Sjövall. 3. Regulation of bile acid synthesis; Z.R. Vlahcevic, et al.
Section II: Bile acid transport. 4. Hepatocellular basolateral bile acid
uptake proteins; B. Hagenbusch, et al. 5. Transcellular bile acid
transport; J.M. Crawford. 6. Bile acid transport across the canalicular
membrane; D. Keppler, et al. 7. The hepatic Na+ taurocholate cotransporter
is downregulated in experimental models of cholestasis; C. Gartung, J.L.
Boyer. Section III: New concepts of bile acid-induced hepatotoxicity and
bile secretion. 8. Effect of bile salts on biomembranes; S. Güldütuna, et
al. Apoptosis - an alternative mechanism of bile salt hepatotoxicity; T.
Patel, et al. 10. Bile acids and hepatocellular signalling; U. Beuers, et
al. 11. Hepatobiliary cholesterol secretion and the function of mdr2
P-glycoprotein; R.P.J. Oude Elferink, et al. Section IV: Bile secretory
function of liver and bile duct cells. 12. Vesicle targeting to the
canalicular domain regulates bile acid transport and bile secretory
function in the liver; J.L. Boyer, et al. 13. Effects of bile acids on bile
duct epithelial cells; M. Strazzabosco, et al. 14. Increased biliary
secretion of phospholipids in primary sclerosing cholangitis: another
mechanism of action of ursodeoxycholic acid? A. Stiehl, et al. 15. Bile
acid transport systems as pharmaceutical targets: bile acid-derived HMG-CoA
reductase inhibitors; W. Kramer, et al. Section V: Ursodeoxycholic acid
treatment in cholestatic liver diseases. 16. Long-term experience with
ursodeoxycholic acid for patients with biliary cirrhosis and primary
sclerosing cholangitis. 17. State of the Art Lecture: Ursodeoxycholic acid
in cholestatic liver diseases &endash; clinical efficiency and putative
mechanism of action; R. Poupon. Index.